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USMLE High-Yield Questions on Instagram: "Big forehead ❌ Big diagnosis ✅ USMLE never forgets the fivehead ⸻ Answer: C) Fragile X syndrome Explanation Fragile X syndrome is caused by CGG trinucleotide repeat expansion in the FMR1 gene on the X chromosome. Key classic features include: • Prominent forehead / long face • Developmental delay / intellectual disability • Macroorchidism (especially post-puberty) • Often associated with autism-like behaviors, hyperactivity, and social anxiety This combo
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