Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ ...
Aug 2, 2023 · Soluble epoxide hydrolase (sEH) is expressed in both peripheral tissues and CNS. Its upregulation has been implicated in multiple neurological conditions, including depression, …
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse ...
Dec 15, 2020 · Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Sci Rep. 2018 Mar 27;8 (1):5279. PubMed. O'Brien CE, Santos PT, Kulikowicz E, Lee JK, …
Soluble epoxide hydrolase: a next-generation drug target for Alzheimer ...
Gregory A, Tang C, Fan F. Soluble epoxide hydrolase: a next-generation drug target for Alzheimer's disease and related dementias. Neural Regen Res. 2025 Sep 1;20 (9):2585-2586.
Could Inhibiting a Liver Enzyme Ameliorate Alzheimer’s ... - ALZFORUM
Aug 2, 2023 · But what if targeting a peripheral enzyme could do the job? In the June 26 Neuron online, researchers led by Xin-Hong Zhu at Shenzhen University, China, reported that inhibiting a liver …
Genetic deletion of soluble epoxide hydrolase delays the progression …
Lee HT, Lee KI, Chen CH, Lee TS. Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer's disease. J Neuroinflammation. 2019 Dec 17;16 (1):267. PubMed.
New Therapeutic Strategy—Mimic the ApoE Christchurch Mutation?
Oct 24, 2023 · Further, a recent study showed that inhibition of liver enzyme soluble epoxide hydrolase drives a subsequent increase of 14,15-epoxyeicosatrienoic acid in the blood and into the brain, …
DNL919 - ALZFORUM
Background This TREM2 agonist antibody activates microglia to phagocytose amyloid. DNL919 contains a transferrin-receptor binding sequence engineered into its Fc domain. Thus, the antibody binds to …
New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
Oct 22, 2024 · Recent studies suggest that when neurons are overwhelmed by oxidative stress, they spew out toxic, peroxidated lipids. Glia then sail in to mop up the spill, containing the oils within …
JOBS - ALZFORUM
Oct 1, 2025 · 58 RESULTS You searched postdoctoral-position-genomics-and-neurodegenerative-diseases Go to another page: Next 1 2 3 4
Gba1 D409V KI Mouse (Grabowski) | ALZFORUM
Jul 16, 2024 · This knock-in (KI) mouse model was generated by introducing a c.A1366T point mutation into exon 9 of the mouse Gba1 (acid β-glucosidase) gene resulting in a D409V substitution (Xu et al., …