Ribozymes are RNA molecules that are capable of catalyzing a chemical reaction. Ribozymes occur naturally inside cells where they play an essential role in the ribosome, joining amino acids together ...
We have selected an allosteric ribozyme ligase from a random sequence population that is activated up to 10,000-fold by oligonucleotide effectors. The ribozyme conforms to a classic two-state model ...
Enzymes enable biochemical reactions that would otherwise not take place on their own. In nature, it is mostly proteins that function as enzymes. However, other molecules can also perform enzymatic ...
Important progress for RNA research: A team has discovered a new ribozyme that can label RNA molecules in living cells. RNA molecules are real all-rounders. They transfer the genetic information from ...
RNA molecules are real all-rounders. They transfer the genetic information from the DNA in the cell. They regulate the activity of genes. And some of them have a catalytic effect: just like enzymes, ...
Rapid progress in the sequencing of several genomes has provided abundant sequence information, but the functions of many of the genes remain to be determined. So, a simple and reliable knockdown tool ...
The "RNA world" hypothesis proposes that the earliest life on Earth may have been based on RNA—a single-stranded molecule similar in many ways to DNA—like some modern viruses. This is because, like ...
In new research published in the journal Angewandte Chemie, scientists applied a high throughput methodology to study the ribozyme in an innovative way. While work in this area has typically used ...
Researchers have developed the first cross-chiral biocatalyst—a right-handed (d) RNA enzyme that catalyzes the linkage of left-handed (l) RNA nucleotides into l-RNA chains. No other RNA or protein ...
Atomic-resolution structure of a ribozyme yields insights into RNA catalysis and the origins of life
Which came first, nucleic acids or proteins? This question is molecular biology’s version of the “chicken-or-the-egg” riddle. Genes made of nucleic acids (DNA or RNA) contain the instructions for ...
Although ribozymes capable of performing a wide range of reactions have been evolved in the lab, only a handful of classes of these RNA-based catalysts are found in nature. Now, a new type of ribozyme ...
A study finds that an RNA enzyme, or ribozyme, can evolve to produce complex RNAs efficiently but at the cost of synthesis accuracy. Key to the development of RNA-based life, which is thought to have ...
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