Pyroptosis is a form of cell death that relies on gasdermins-mediated formation pores in the plasma membrane, which subsequently promotes inflammation by releasing immunogenic cellular contents. The ...

Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3, interleukin-1β, and interleukin-18 in macrophages within ...

Ulcerative colitis, one type of chronic inflammatory bowel disease, is driven by a form of programmed cell death called pyroptosis.

Non-steroidal anti-inflammatory drugs (NSAIDs) are classically defined by cyclooxygenase (COX) inhibition, yet increasing evidence shows that many NSAIDs ...

Inflammasomes are more active in the morning than the rest of the day. Macrophage activity, which regulates inflammation, is influenced by the biologic clock in the body. A team led by Annie Curtis, ...

Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs, MDSCs, and Tregs-orchestrate a tumor-permissive microenvironment.