The latest short science news items from C&EN. Proteins are vital for life, involved in virtually every biochemical process that makes life possible. They comprise one or more amino acid chains ...

The strategies biopharmaceutical manufacturers currently use to limit protein misfolding are complex, time-consuming, and generate low yields with only limited scalability. Covalent organic frameworks ...

A SLAC-Stanford study revealed four intermediate steps in folding a human protein called tubulin, all directed by the inner walls of a cellular machine called TRiC (yellow). The process starts when a ...

Scientists have unraveled the step-by-step activation process of a protein with a deep evolutionary history in all domains of life, opening the door to harnessing its functions for use as a ...

Scientists discovered a role played by ribosomes during the folding of new proteins in cells. Scientists at UCL have discovered a novel role played by ribosomes during the folding of new proteins in ...

An illustration showing how the nascent polypeptide-associated complex (NAC, green) at the ribosome (blue) helps the amino acid chain (white) to fold into a protein. In the earliest phase of creating ...

Gram-negative bacteria that are resistant to multiple drugs cannot survive without the cell-surface machinery that builds a β-barrel pore structure from outer membrane proteins. Snapshots of different ...

When a protein folds, its string of amino acids wiggles and jiggles through countless conformations before it forms a fully folded, functional protein. This rapid and complex process is hard to ...

For those outside the chemistry cognoscenti, the announcement might have seemed little more than researchers patting each other on the back. But the question of protein folding had plagued scientists ...

Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions. This folding process occasionally goes awry, resulting in misfolded proteins ...