Subtle changes in neurotransmission that occur during Alzheimer’s disease have been tough to track in living people. A new positron emission tomography tracer may change that. In the January 12 ...

Researchers have identified a mechanism by which acetylcholine, a neurotransmitter best known for its role in muscle control and attention, can effectively commandeer serotonin release inside the ...

Muscarinic acetylcholine receptors (mAChRs) are central to the modulation of neurotransmission in the human brain and are emerging as promising targets in the management of neuropsychiatric disorders.

The production of toxic Aβ peptides from amyloid precursor protein (APP) proceeds via the sequential cleavage of the extracellular domain by β-secretase, followed by an intramembrane cut by ...

Introduction Studies on human patellar and Achilles tendons have shown that tendon cells not only have the capacity to produce acetylcholine (ACh) but also express muscarinic ACh receptors (mAChRs), ...

Cocaine, opioids, and other drugs of abuse disrupt the brain's reward system, often shifting users' priorities to obtaining more drug above all else. For people battling addiction, this persistent ...

2 Department of Psychiatry, University of Toronto, Faculty of Medicine, 33 Russell Street, T-109 Toronto, ON M5S 2S1, Canada 3 Multimodal Imaging Group, Centre for Addiction & Mental Health, Toronto, ...

Sumitomo Pharma Co. Ltd. has patented aminomethylcyclohexane derivatives acting as muscarinic M4 receptor antagonists. As such, they are described as potentially useful for the treatment of ...