MeCP2 is a methyl DNA–binding transcriptional regulator that contributes to the development and function of CNS synapses; however, the requirement for MeCP2 in stimulus-regulated behavioral plasticity ...

Rett syndrome (RTT) is unique among genetic, chromosomal and other developmental disorders because of its extreme female gender bias, early normal development, and subsequent developmental regression ...

This release is available in Spanish. A paper published online today in Molecular Cell proposes that Methyl CpG binding protein 2 (MeCP2) impacts the entire genome in neurons, rather than acting as a ...

One particular protein lies at the heart of brain development. A master regulator of gene expression, it's abundantly present in neurons, and its dysfunction underlies Rett syndrome, a neurological ...

A new article proposes that Methyl CpG binding protein 2 (MeCP2) impacts the entire genome in neurons, rather than acting as a regulator of specific genes. Mutations in MeCP2 cause the autism spectrum ...

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital and collaborating institutions have gained new insights into the ...

The protein MeCP2 is porridge to the finicky neuron. Like Goldilocks, the neuron or brain cell needs the protein in just the right amount. Girls born with dysfunctional MeCP2 (methyl-CpG-binding ...

Researchers are combining in vivo experimentation with computation for highly accurate prediction of the genome-wide binding pattern of a key protein involved in brain disorders. Researchers from the ...

Rett syndrome is a rare devastating neurological disorder that primarily affects young girls and manifests as an impaired ability to walk and talk, along with characteristic 'hand-wringing' movements, ...

Rett syndrome is a rare disorder linked to autism that affects brain development. Microglia, the resident immune cells of the central nervous system, have been implicated in the development of Rett ...

Modulating alternative splicing of the MECP2 gene has been identified as a potential therapeutic strategy for Rett syndrome. A team of researchers at Texas Children’s Duncan Neurological Research ...

In the February 9 Science, Adrian Bird and colleagues at Edinburgh University, Scotland, report striking results of a “cure” for Rett syndrome mice. Rett’s (RTT) is an X-linked autism spectrum ...