Enzymes inside cells tweak and modify amino acids to change proteins’ structure and function. But some amino acids also undergo a transformation called deamidation without the help of an enzyme.

This study is reported by Jian-Feng Li’s group from School of Life Sciences, Sun Yat-sen University, Guangzhou. Necrotrophic fungal pathogens, such as Botrytis cinerea and Sclerotinia sclerotiorum, ...

Deamidation of asparagine (Asn) is a spontaneous and non-enzymatic post-translational modification in proteins, playing a significant role in diseases related to aging such as Alzheimer’s and ...

The JAK2V617F mutation is found in most patients with a myeloproliferative neoplasm (MPN). This gain-of-function mutation dysregulates cytokine signaling and is associated with increased accumulation ...