DNA polymerases orchestrate the faithful replication and repair of genomes through a coordinated sequence of substrate binding, chemical catalysis and product release. Central to this process are ...
DNA polymerases rely on divalent metal ions to catalyse the nucleotidyl transfer reaction and to ensure high fidelity during genome replication and repair. The classical two-metal-ion mechanism ...
When TV shows like CSI: Crime Scene Investigation portray DNA processing in the forensic lab, the results appear instantly with a DNA match wrapping up the case in hours. However, the ...
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