Many tumour cells exhibit high rates of glutamine consumption to support macromolecular biosynthesis and cell proliferation 1. Glutamine fuels the tricarboxylic acid (TCA) cycle through anaplerosis ...
CRISPR editing targeted the asparagine synthetase-2 (TaASN2) gene, responsible for asparagine production. One edited line also included a partial knockout of the related TaASN1 gene. These targeted ...
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