Oxidizing the end carbon atom of a terminal alkene to form an aldehyde, a process called anti-Markovnikov alkene oxidation, is difficult because the reaction is energetically unfavorable. The ...
Enantioselective α-alkylation of carbonyl is considered as one of the most important processes for asymmetric synthesis. Common alkylation agents, that is, alkyl halides, are notorious substrates for ...
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